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N.K. Kochetkov Laboratory of Carbohydrate Chemistry
N.D. Zelinsky Institute of Organic Chemistry
Russian Academy of Sciences
Leninsky Prospekt 47, 119991 Moscow, Russia
Phone/fax: +7 499 1376148
Web-site: http://www.glyco.ac.ru/Lab
RESEARCH PROJECTS
[Main current projects]
[Other current projects] [Past projects]
Synthesis of glycosylamines of mono- and oligosaccharides and neoglycoconjugates of new type therefrom
Supported by
Elaboration of new approaches to stereodirected synthesis of sialic acid-containing oligosaccharides. Studies of the influence of intermolecular interactions in solution on chemical reactions of carbohydrate derivatives
Supported by
New strategy of block synthesis of oligosaccharide fragments of the arabinan domain of the mycobacterial cell wall lipoglycans and neoglycoconjugates thereof as potential agents for diagnostics of mycobacterioses
In cooperation with
Supported by
Chemical synthesis of analogs of polyprenyl phosphates and dolichyl phosphates for characterization of bacterial glycosyltransferases
In cooperation with
Supported by
Determination of O-antigen structures and sequencing of O-antigen gene clusters for elucidation of the O-antigen biosynthesis gene functions and the evolutionary history of the O-antigen gene clusters of Shigella, Escherichia, Salmonella, Providencia, Enterobacter and Cronobacter
In cooperation with
Supported by
Elucidation of new serotype conversion mechanisms and improvement of the O-antigen-based classification scheme of Shigella flexneri, a cause of shigellosis
In cooperation with
National Institute for Communicable Disease Control and Prevention, China CDC, Beijing, China
Supported by
Structure elucidation of capsular polysaccharides of Acinetobacter baumannii and mechanisms of their depolymerization by specific bacteriophages
In cooperation with
Supported by
Determination of lipopolysaccharide structures for elucidation of its relationship to the ability of the bacteria to activate the innate immune system
In cooperation with
Supported by
Synthesis of oligosaccharide fragments of O-specific polysaccharides and neoglycoconjugates thereof as antigens for serological classification of rhizobacteria of the genus Azospirillum
In cooperation with
Supported by
Isolation and characterization of bacterial carbohydrates for construction of pathogen glycoarray - a tool for studies of carbohydrate-protein interactions
In cooperation with
Supported by
Structural studies of polysaccharides and teichoic acids of the cell wall of actinomycetes
In cooperation with
Supported by
International Association for the Promotion of Co-operation with Scientists from the New Independent States of the Former Soviet Union (INTAS), 2001-2003
Studies of lipopolysaccharides of new genera of enterobacteria - Rahnella, Pragia, Budvicia; their relationships with the classical representatives of the family Enterobacteriaceae
In cooperation with
Supported by
Structure-function and genetic studies of the lipopolysaccharide of enthomopathogenic bacteria Photorhabdus spp. differing in pathogenicity for humans
In cooperation with
Supported by
Structural studies of polysaccharides and lipopolysaccharides of diazotrophic rhizobacteria
In cooperation with
Supported by
Federal Targeted Program Integration of science and higher education in Russia, 2003-2004
Studies of polysaccharide antigens of probiotic microorganisms bifidobacteria and lactobacteria
In cooperation with
Supported by
Elaboration, creation, and maintenance of the Internet-based Bacterial Carbohydrate Structure Database (BCSDB)
In cooperation with
Supported by
Structural studies of gangliosides of Echinodermata. A taxonomic aspect
Elaboration of methods of specific degradations of heterocyclic bases in nucleotides and nucleic acids (1962-1978)
Synthesis of glycopeptids and other derivatives of sugars with amino acids - model compounds for studies of chemical behavior of glycoproteins (1960-1971)
New methods for synthesis of unusual natural monosaccharides and their derivatives, including deoxy sugars, amino sugars, and higher monosaccharides (1960-1975)
Identification and synthesis of new monosaccharides and non-carbohydrate components of natural polysaccharides (1975-2001)
Elaboration of new stereospecific glycosylation methods. Orthoester, cyanoethylidene, thioorthoester, and thiocyanate methods of glycosylation (1963-1995).
Studies of kinetics and mechanism of the reaction, influence of pressure on the stereoselectivity (1986-1996)
Supported by
International Science Foundation (Soros Foundation), 1994-1995
Directed chemical synthesis of regular polysaccharides (1966-1993). Synthesis and trityl-cyanoethylidene polycondensation of oligosaccharides corresponding to repeating units of antigenic polysaccharides of bacteria (1974-1989)
Development of methods for synthesis of carbohydrate-containing artificial antigens by copolymerization of allyl glycosides or acryloylaminoalkyl glycosides of synthetic oligosaccharides with acrylamide, their use for serodiagnostics of salmonellosis (1979-1992)
Synthesis and studies of biological action of oligosaccharines - natural regulators of growth and development of plants, their analogs and derivatives (1990-1997)
In cooperation with
Supported by
Elaboration of new ways of application of monosaccharides as chiral synthons for synthesis of aglycones of macrolide antibiotics and other carbocyclic systems (1977-1995)
Supported by
International Science Foundation (Soros Foundation), 1995
Radiation chemistry of carbohydrates. Studies of pathways and products of radiolysis of monosaccharides and related compounds (1964-1977)
Synthesis of uridine diphosphate glucose analogs with modified nucleoside and sugar residues and studies of their interaction with enzymes (1961-1975)
Chemical synthesis of glycosyl phosphates and polyprenyl phosphates - fragments of substrates and inhibitors of enzymatic reactions (1969-1999).
Development of methods for synthesis of glycosyl phospho sugars - fragments of bacterial polymers with repeating units connected by phosphodiester bonds (1987-1990)
In cooperation with
Supported by
Russian Academy of Sciences in the framework of the Agreement on Scientific and Technical Cooperation Between Russian Academy of Sciences and Polish Academy of Sciences, 1986-1999
International Science Foundation (Soros Foundation), 1994-1995
Studies on biosynthesis of the O-antigens of Salmonella and some other bacterial polysaccharides using chemically synthesized activated sugar derivatives (1974-1999). Chemoenzymatic synthesis of O-antigenic polysaccharides (1982-1988)
In cooperation with
Supported by
Elucidation of biosynthetic pathways of exopolysaccharides of nodulating bacteria Rhizobium leguminosarum (1999-2006)
In cooperation with
Supported by
Elaboration of chemical methods of selective cleavage and modification of polysaccharides, cleavage and analysis of carbohydrate chains of glycoproteins,
of methods of electron impact mass spectrometry of monosaccharide and oligosaccharide derivatives, NMR spectroscopy of oligosaccharides and polysaccharides, including computer-assisted 13C NMR-based analysis (1962-2002)
Structure elucidation of triterpene glycosides (oligosides) of plants of Siberia and Far East used in medicine (1960-1967)
In cooperation with
Institute of Biologically Active Compounds, Far-Eastern Scientific Center of the Russian Academy of Sciences, Vladivostok
Isolation and structure elucidation of cerebrosides - mammalian brain glycolipids (1961-1968)
Structural studies of blood group substances from stomach mucosa of animals and humans (1963-1982).
Isolation and structural studies of carbohydrate chains of influenza virus glycoproteins (1983-1990), riboflavin-binding glycoprotein of chicken egg-white (1987-1991), and other glycoproteins
Supported by
State Scientific and Technical Program New bioengineering methods, 1993-1995
Structural studies of gel-forming sulfated polysaccharides of marine red alga (1967-1975)
In cooperation with
Structure elucidation of O-antigenic polysaccharides of medically important bacteria [Shigella (1971-1987),
Pseudomonas aeruginosa (1980-1987), Francisella tularensis, and Burkholderia (Pseudomonas) pseudomallei (1991-1992)],
phytopathogenic bacteria [Xanthomonas campestris, Ralstonia (Pseudomonas) solanacearum, Pseudomonas syringae (1987-2004)],
extracellular polysaccharides of Lipomycetes (1973-1980) and mycobacteria (1979-1984)
In cooperation with
Supported by
International Association for the Promotion of Co-operation with Scientists from the New Independent States of the Former Soviet Union (INTAS), 1997-2001
Synthesis of b-cyclodextrin derivatives and insertion compounds on their basis (2001)
In cooperation with
Supported by
Federal Targeted Program Integration of science and higher education in Russia, 2001
Structural and functional aspects of lipopolysaccharides (endotoxins) of the Legionnaires' disease bacterium Legionella pneumophila, (1992-2002), the cause of Asiatic cholera Vibrio cholerae (1995-2001),
gastric bacterium Helicobacter pylori (1997-2004), the blue pus bacillus Pseudomonas aeruginosa (1997-2006)
In cooperation with
Supported by
International Association for the Promotion of Co-operation with Scientists from the New Independent States of the Former Soviet Union (INTAS), 1999-2001
Synthesis of analogs and labeled derivatives of lipochitooligosaccharides - nodulation factors of rhizobia (1995-2007)
Supported by
International Association for the Promotion of Co-operation with Scientists from the New Independent States of the Former Soviet Union (INTAS), 1995-1996
Synthesis of N-acetylglucosamine oligosaccharides and their use for epitope mapping and vaccine development against staphylococcal infections (2005-2007)
In cooperation with
Supported by
Stereodirected synthesis of polyprenyl phosphates of N-acetylneuraminic acid - key intermadiates of polysialic acid biosynthesis in bacteria (2002-2008)
Supported by
Synthesis of linear and branched mannooligosaccharides - fragments of carbohydrate chains of glycoproteins and bacterial polysaccharides (1999-2009)
Supported by
Synthesis of carbohydrate chains of glycolipids of the globo series as glycosides with a functionalized aglycone - precursors of neoglycoconjugates, tools for studies of interaction of carbohydrate ligands with lectins (2005-2008)
Supported by
Synthesis of carbohydrate-(car)borane conjugates on the basis of spacered O- and N-lactosides as potential tumor selective delivery agents for boron neutron capture therapy of cancer. Elaboration of approaches to directed modulation of physico-chemical properties of neoglycoconjugates and their binding capacity to lectins (2002-2010)
In cooperation with
Supported by
Basic Research Program of the Presidium of the Russian Academy of Sciences Directed synthesis of substances of given properties and creation of useful materials on their basis, 2003-2005
Synthesis and studies of biological properties of cationic derivatives of polyprenols and prenylated peptides (1999-2009)
In cooperation with
Supported by
Russian Academy of Sciences in the framework of the Agreement on Scientific and Technical Cooperation Between Russian Academy of Sciences and Polish Academy of Sciences, 1999-2007
Federal Targeted Scientific and Technical Program New materials and chemical products, 1999-2001
Genetic control of the structure and biological properties of the lipopolysaccharide of the tularemia bacteria (2008-2009)
In cooperation with
Supported by
Elucidation of biosynthesis pathways of monosaccharides - specific components of antigenic polysaccharides of bacteria (2007-2010)
In cooperation with
Supported by
Determination of structures of the O-specific polysaccharides (O-antigens) for classification of enterobacteria Proteus, Citrobacter, Hafnia, and Edwardsiella (1986-2013)
In cooperation with
I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia
Center of Microbiology and Virology, Polish Academy of Sciences, Lodz, Poland
Supported by
Russain Academy of Sciences in the framework of the Agreement on Scientific and Technical Cooperation Between Russian Academy of Sciences and Polish Academy of Sciences, 1986-2007
International Science Foundation (Soros Foundation), 1994-1995
Structure-function and genetic studies of the lipopolysaccharides of the plague bacterium Yersinia pestis and its ancestor Yersinia pseudotuberculosis, the cause of pseudotuberculosis (2001-2012)
Development of methods for structural analysis of lipopolysaccharides by high-resolution mass spectrometry
In cooperation with
Supported by
Structure elucidation of cell surface polysaccharides of marine microorganisms
In cooperation with
Studies on structure and biosynthesis of the lipopolysaccharide of Aeromonas hydrophila (2002-2012)
In cooperation with
Design of novel dual function anomeric protective groups for synthesis of biologically important oligosaccharides and neoglycoconjugates
Supported by
Design and production of diagnostic 13C-labeled glucose preparations
In cooperation with
Supported by
All projects are performed in co-operation with the NMR Center of the N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences.
Since 1996, the projects are supported by the Council on Grants at the President of the Russian Federation for Support of Leading Scientific Schools and Young Russian Scientists.
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